A simple and sensitive HPTLC method has been developed for determination of Metoprolol succinate and Telmisartan in its pharmaceutical dosage forms. The method employed HPTLC aluminium plates precoated with silica gel 60F-254 as the stationary phase. Toluene: Ethyl acetate: Methanol: Glacial acetic acid (6:2:2:0.1v/v/v/v) as a mobile phase at ahe room temperature. The Rf value of metoprolol succinate is 0.25 and of Telmisartan is 0.64 were found. The linearity for both the drugs was in the range of 1000-5000 ng/ml and 800-4000 ng/ml. The % recoveries of metoprolol succinate and telmisartan were found to be in the range of 99.17-99.72 and 99.07-99.45, respectively. The proposed method was validated and successfully applied to the estimation of metoprolol succinate and telmisartan in combined dosage form.
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